What is NMN and Are There Any Side Effects?
Imagine being able to put a stop to aging, pull it back or even slow it down? How about having the energy of a 20-year-old in your 50s? Or turning back the hormonal clock and reversing menopause? These wishes are not so far off anymore! In fact, scientists have been studying a particular molecule in the labs and have now found an aging elixir. If you have heard about NMN and want to know more about what it can do for you and how to get the best results, read on!
According to a 2018 study by Dr. Satchidananda Panda on time-restricted feeding, longevity has much to do with when you eat as opposed to what you eat. There are processes in the body that diet, exercise, calorie restriction, and intermittent fasting activates that make us healthier and live longer.
This is where it gets even more interesting! Scientists have figured out a large part of the chemistry involved in the above, and are now using β-Nicotinamide Mononucleotide (NMN), a molecule, to mimic the processes. According to scientists, when NMN is added to diet and exercise, it performs even better in fighting off aging without leaving behind any side effects.
If you’ve committed to anti-aging therapy, there is a chance that you already have a diet plan in place, complete with a workout regime and probably a few supplements. Many people in the anti-aging field today supplement with NMN to augment what they cannot get naturally. This brings us to the question: what is NMN?
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WHAT IS NMN AND HOW DOES IT RELATE TO AGING AND LONGEVITY?
It all happened about 20 years ago at M.I.T (Massachusetts Institute of Technology) when Leonard Guarente, a biology professor, and a team of other scientists discovered SIRT1 genes (Sirtuins) in yeast.
Sirtuins control aging: seven of them are found in humans and five in yeast. Essentially, they protect all organisms on the planet, including humans, from deterioration and disease. They work amongst many cellular pathways that control cell death, turn anti-aging genes on and off, help repair DNA, and regulate metabolism. SIRT 1 is one of the four longevity pathways.
When more of these genes were put in organisms, the organisms’ lifespans extended by 5 to 20 percent. It was with this discovery that scientists began mimicking the genes using molecules. One of the molecules they used was NMN and the other, resveratrol.
NMN is a Vitamin B3 (niacin) derivative. It occurs naturally and can be made from dietary sources such as fruits, milk, and vegetables. In the body, NMN is used to generate nicotinamide adenine dinucleotide (NAD+), a powerful and essential molecule that is found in every cell of the body. Believe it or not, if NAD+ levels in your body drop to zero, you’d be dead in about 30 seconds.
Also, and probably the most important when it comes to longevity and the fight against aging, NAD+ plays a crucial role in activating Sirtuins. As a matter of fact, without NAD+, the SIRT1 genes can’t work and perform their role of protecting our bodies from deterioration and disease.
Unfortunately, as we age, the levels of NAD+ fall. By the time we are 50 years old, for most of us, our NAD+ levels are about half of what they were when we were 20. This decrease in NAD+ interferes with SIRT1’s ability to defend our bodies and slow down the aging process.
WHAT FOODS CONTAIN NMN?
NMN occurs naturally in food such as avocado, broccoli, cabbage, and tomatoes. Now, you might be thinking: “If NMN is found in food, can’t I increase my levels of NAD+ by eating more of those foods? ” That’s a good question and we do encourage you to eat a healthy diet. But, here’s the issue:
Although NMN occurs in these foods, the concentrations are less than 1 mg per kg of food. In other words, to get about 1mg of NMN, you’d have to eat about 1kg of broccoli!
It’s been found that to boost the levels of NAD+ in humans, the levels of NMN should be in the hundreds of milligrams per dose. This is way higher than what we can get from our diets, no matter how much broccoli we eat.
Is NMN better than NAD+?
For many years, it was thought that the NAD+ molecules were too large to be taken directly and needed to be raised using a precursor such as NMN. Recently, it has been found that NAD+ can cross the blood-brain barrier and to reach the hypothalamus if taken sublingually. It can boost NAD+ levels in this gland which will benefit the entire body because it controls the metabolism. It’s can also be a potential supplement to help those who have metabolic disorders because of decreased NAD+ levels in the hypothalamus.
NMN, on the other hand, elevates NAD+ levels in cells throughout the body and is a better supplement to take to boost your overall NAD+ levels and slow aging.
CAN NMN BOOST YOUR IMMUNE SYSTEM AGAINST CORONAVIRUS?
According to clinical trials, NMN supplements boost NAD+ to youthful levels. Making the NAD+ molecule available to SIRT1 genes enhances their ability to protect the body against disease and deterioration. As more studies are being conducted, researchers are finding that NAD+ also has an important role to play in regulating our immune systems.
In addition, studies have shown that NAD+ can trigger an immune system response to protect the body from a coronavirus such as COVID-19. A review published March 23, 2020 by Isfahan University of Medical Sciences provides evidence that low NAD+ levels could be tied to higher severity and morbidity rates in the COVID-19 pandemic
“In the depicted molecular pathology pathway of COVID-19, almost all procedures lead to or originate from NAD+ depletion. Consumption of NAD in large amounts to repair DNA decreases ATP levels leading to impairment of all activities and integrity of the cell.”
“Taking NAD+ or Vitamin B3 plus L-tryptophan could replenish
NAD+ and serotonin and recover the body toward hemostasis.”
They’ve also found that macrophages (a type of white blood cell that eats potential invaders such as bacteria, fungi, parasites, and viruses) use a pathway synthesized by NAD+ to ensure cell survival and control inflammation.
All in all, studies are indicating that NMN and the resulting increased levels of NAD+ can play an important role in helping our bodies fight off infections and bacteria. In other words, it has the potential to boost our immune systems and help them during times of infection and illness.
WHAT IS NMN GOOD FOR?
It’s almost, if not totally impossible, to discuss NMN benefits without looking at the longevity pathways. There are four main longevity pathways identified in organisms including humans:
There are four main longevity pathways identified in organisms including humans:
When activated, each of these pathways regulates lifespan and aging. NMN together with resveratrol work through the SIRT1 Pathway to stop or backpedal the effects of aging. Below are the specific benefits of NMN in activating the body’s defenses against aging.
NMN boosts energy supply in aging cells
Cells take in and process fuel to power their functions. As you age they lose this ability, forcing them into a condition known as cellular senescence or biological aging that comes with other detrimental effects.
Previously, NAD+ which is a key element of the cell’s fuel supply was thought to be the only route through which NMN can contribute to cell energy. However, a groundbreaking Washington University School of Medicine study published in the Nature Metabolism journal shows that NMN can be delivered directly into cells without conversion to NAD+.
This direct and faster delivery is possible with the help of a mystery transporter protein called Slc12a8. Another interesting discovery is that Slc12a8 is automatically dialed up by cells when NAD+ levels fall.
This means that supplementing with NMN gives your cells a much quicker path to refuel and promotes cell division and growth.
NMN helps in fighting metabolic diseases
As you age, conditions such as diabetes, obesity, dyslipidemia, and non-alcoholic fatty liver disease (NAFLD) become prevalent. They are caused by a reduction in NAD+ levels. NMN works through the salvage pathway to boost the levels of NAD+ thereby ameliorating these and other metabolic diseases.
Imagine being 90 and disease-free. You can literally run around with your grandchildren like a 50-year-old! It is possible to achieve this level of youthfulness with NMN supplements.
NMN reactivates faltering blood flow
According to a 2018 study published in the Cell journal, aging mice with a compromised blood flow experienced a reactivation of their blood flow after taking NMN.
The researchers, led by Dr. David Sinclair, a co-director at Paul F. Glenn center at Harvard Medical School, found that as the body ages, the number and functions of endothelial cells (ECs) lining the blood vessels decline.
This capillary decline affects the supply of nutrients, oxygen, exchange of heat, and removal of waste products. If nothing is done to stop or reverse this loss, it accelerates the aging process and along with it comes age-related complications.
Have you found yourself struggling to exercise or wished you could last longer on a treadmill? Well, this is the reason behind the decline in strength and endurance you are experiencing as you age.
However, all is not lost! The study found that NAD+ precursors such as NMN and nicotinamide riboside (NR) working through the Sirtuin Pathway, can help restore the capacity of endothelial cells to form new blood vessels.
There you go, another reason to boost your NAD+ levels with NMN supplements!
Most probably this supplement is already on the watch list of most professional sports teams in America because of its ability to enhance performance by boosting the blood flow. We all hope they get it fast before the World Anti-Doping Agency (WADA) comes knocking!
"By the turn of the next century, a person who is 122 on the day of his or her death may be said to have lived a full, though not particularly long, life."
- BIOLOGIST DAVID SINCLAIR
CAN NMN REVERSE MENOPAUSE?
Dr Sinclair and his team initially focused their research on male subjects. However, when they started adding NMN to the water of aged post-menopausal female subjects, they noticed an interesting observation: they were able to reproduce for longer. When they studied the egg cells, they found that the DNA and chromosomes were normalized to that of the equivalent of a younger egg cell, and they were able to reproduce once more.
The results of their research indicate that NMN may be effective in slowing down and possibly even reversing menopause. It also holds great potential as a fertility treatment that is non-invasive.
You can find out more about this at the 9 minute mark: https://www.abc.net.au/catalyst/live-long-die-young/11016576
DOES NMN HAVE ANY SIDE EFFECTS?
Scientists have researched NMN extensively. To date, there is no evidence that shows any negative side effects.
Dr. David Sinclair named one of the 100 most influential people in the world by Time Magazine, has been taking NMN supplements for years with friends in the aging industry. To date, he hasn’t experienced any side effects except when NMN is stored in hot/warm temperatures. When this happens, NMN degrades to Nicotinamide poison your body. Therefore, it’s very important to always store your NMN in a cool climate or ideally in a fridge.
If you notice symptoms of reduced effectiveness of NMN such as decreased sleep quality and reduced memory, it might be beneficial to cycle off NMN for one week to allow the body the occasional break.
If you’d like to listen to a podcast where he talks about his research and NMN, you can listen to it here: The Joe Rogan Experience — David Sinclair, Ph.D.
IS NMN SAFE?
A human trial was recently conducted out of Japan. The purpose of the trial was to determine if NMN was safe to take. NMN was administered to 10 healthy men. Dosages of 100, 250, and 500 mg NMN were given. The single oral administrations of NMN did not cause any significant clinical symptoms or changes in main biomarkers like heart rate, blood pressure, oxygen saturation, and body temperature. The trial helps to confirm that, in general, NMN is safe and well-tolerated; to that end, the trial can be considered a success.
HOW MUCH NMN SHOULD YOU TAKE DAILY?
So what is the recommended dose of NMN?
We recommend the following daily dosages for NMN based on customer feedback based on age.
30-40 years old: 200-400 mg/day
40-50 years old: 400-600 mg/day
50-60 years old: 600-800 mg/day
Over 60 years old: 800-1200 mg/day
Another method to calculate the required NMN dose is to take your weight is based on the following study. Given that 100 mg/kg/day of NMN was able to mitigate most age-associated physiological declines in mice, an equivalent surface area dose for humans would be ~8 mg/kg/day.
As an example, if you weigh:
50kg then multiply by 8 mg = 400 mg per day
60kg then multiply by 8 mg = 480 mg per day
70kg then multiply by 8 mg = 560 mg per day
80kg multiply by 8 mg = 640 mg per day
90kg multiply by 8 mg = 720 mg per day
100kg multiply by 8 mg = 800 mg per day
WHEN TO TAKE NMN
We recommend you take NMN on an empty stomach first thing in the morning even if you’re fasting. Don’t mix the sublingual NMN with juice or water, it will reduce the bioavailability. For maximum effectiveness, take it directly under the tongue as directed.
Also to improve your NAD+ levels, you can take the delayed-release NMN capsules with a Sirtuin Activator such as a Resveratrol with a full-fat yogurt which helps the bioavailability of Resveratrol.
DO I NEED TO TAKE TMG (TRIMETHYLGLYCINE) WITH NMN?
There is concern that NMN depletes methyl groups within our bodies and, therefore, as a precaution, it’s thought to be important to take TMG (an amino acid known as betaine) to donate methyl groups especially if you have been taking NMN for a long period.
In the podcast below with Dr. Mercola, Dr. David Sinclair mentioned that he takes TMG as a precaution to prevent this from happening because, at the moment, the research is not clear [the topic is covered from about 22:00 minutes].
WHAT IS METHYLATION?
Methylation is a critical biochemical process that occurs in the cell when a methyl group (consisting of one carbon atom and three hydrogen atoms) is transferred from one molecule to another to help that molecule perform its function.
In a nutshell, because of the methylation cycle, methyl groups are required for many crucial processes in our bodies such as producing neurotransmitters and antioxidants, epigenetics (how DNA expresses itself), regulating cardiovascular and nervous system activity, energy production, and heavy metal detoxification. Our bodies have a reserve of methyl groups that it uses whenever it requires methylation for cellular processes and functions.
When NMN is converted into NAD+, nicotinamide (NAM) is formed. High levels of nicotinamide are not good for our bodies and in order for our bodies to get rid of nicotinamide it needs to be methylated into N-methyl nicotinamide that is excreted in our urine. In order to methylate NAM, the body theoretically draws from our reserves of methyl groups. The theory is that the more NMN you take, the more methyl groups are required to get rid of the NAM. And, this might cause a lack of methyl groups to perform all the other critical functions that require methylation which could lead to a whole host of health conditions. To prevent this from happening, you can take TMG which donates a methyl group and keeps your methyl reserves high. It’s important to note that Dr. Sinclair says that he can’t say for sure that this happens because the research isn’t clear. Here is a comprehensive video that covers the topic in detail:
Although TMG is reportedly safe and beneficial to our bodies, it’s always best to check with your healthcare practitioner before starting to take it, especially if you have a health condition and are using chronic medication. Always follow the recommended dosage.
ANTI-AGING BENEFITS OF NMN
NMN has been at the forefront in studies aimed at understanding and possibly reversing the aging process. The role of NMN as a precursor to NAD+ is critical in boosting longevity and we’ve listed many of its benefits above. But, here are two more ways NMN fights aging:
NMN suppresses age-related weight gain
As people age, they gain weight. In a 2016 study, it was found that subjects given NMN saw their fat mass decrease and lean mass increase. By supplementing with NMN, you can lose weight and build muscle—two powerful ways to improve muscle health and look and feel younger!
NMN boosts energy metabolism
By mediating the synthesis of NAD+, NMN helps in breaking the nutrients into energy, powering important cell functions and reducing oxidative stress. These biochemical processes slow down and potentially halt the aging process. NMN not only boosts your energy but helps in repairing your cells!
WHY SUPPLEMENT WITH NMN?
As we have shown, NMN plays a crucial role in creating NAD+. When we have high levels of NAD+ in our bodies, cellular energy increases which becomes the fuel of life—powering every organ and cell in our bodies and protecting us from DNA damage. NAD+ also activates Sirtuins which are essential in increasing our life expectancy and slowing down the aging process.
Supplementing with NMN directly increases the levels of NAD+ in our bodies, which counteracts the natural decline that occurs as we age. Research has shown that by supplementing with NMN, the NAD+ levels in older people can be raised to that of a 20-year-old!
No one wants to be 90 and frail; 90 may even be the new 50! Whether in exercise or mental competence, we all want to perform as better or even more than we did when we were younger.
Over and over we are told that aging is an inevitable process and we just have to accept and manage our failing systems. But, what if we told you that the DNA damage, free radicals, oxidation, and mutation processes being touted as the reasons behind aging are to a larger extent false? What if we gave you an alternative by activating your longevity pathway that slows down, stops or reverses the aging process? Wouldn’t you make use of the opportunity?
Supplementing with NMN in conjunction with a healthy diet and lifestyle gives your system a fighting chance at growing older. Youth & Earth’s NMN supplement is is available as a capsule, or powder that can be taken sublingual. We supply NMN to the UK and Europe so don’t miss out on this opportunity to bring back your youthful zest and feel younger for longer! If you are looking for a trusted supplier of NMN look no further.
The content of this article is for informational purposes only. It’s not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or health provider before starting a new health regime or program. Do not ignore medical advice or delay seeking it because of something you’ve read on this site or any Youth & Earth product.
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